Co-Electrospun Poly(ε-Caprolactone)/Zein Articular Cartilage Scaffolds

Osteoarthritis scaffold-based grafts fail because of poor integration with the surrounding soft tissue and inadequate tribological properties. To circumvent this, we propose electrospun poly(ε-caprolactone)/zein-based scaffolds owing to their biomimetic capabilities. The scaffold surfaces were characterized using Fourier-transform infrared spectroscopy, X-ray photoelectron static water contact angles, profilometry. Scaffold biocompatibility properties assessed by measuring protein adsorption (Bicinchoninic Acid Assay), cell spreading (stained F-actin), metabolic activity (PrestoBlue™ Cell Viability Reagent) primary bovine chondrocytes. data show that zein surface segregation in membranes not only completely changed hydrophobic behavior materials, but also increased yield on scaffolds. is verified peak at 1658 cm−1, along presence increase N1 content survey XPS. This observation could explain decrease angles from 125° approximately 60° zein-comprised materials both serum albumin synovial fluid half. Surface nano roughness PCL/zein samples additionally benefited radial study showed co-electrospun have promising for use articular-tissue-engineering applications.